“Heavily mutated” is not a term that you should casually throw around, as in “you’re a good friend but heavily mutated” or “would you like to try this heavily mutated food?” But the term could apply to a new Covid-19 coronavirus variant, currently known as the B.1.1.529 variant, that’s been recently detected in Botswana and South Africa. This version of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has over 50 mutations in total with over 30 changes to the spike protein. While many of these mutations have already been present in other existing SARS-CoV-2 variants, such as that darn Delta variant, this B.1.1.529 variant could be the winner if a “variant with the most mutations” title were awarded today.